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KMID : 1039220190290010042
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Journal of Korean Society of Occupational and Environmental Hygiene
2019 Volume.29 No. 1 p.42 ~ p.49
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Iron deficiency in Retired Workers exposed to Mineral dust with Chronic Obstructive Pulmonary Disease
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Lee Jong-Seong
Shin Jae-Hoon
Baek Jin-Ee
Jeong Ji-Young
Kim Hyeong-Geun
Choi Byung-Soon
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Abstract
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Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Iron deficiency is associated with chronic inflammation, such as COPD. The aim of this study was to evaluate the relationship among iron deficiency, iron homeostasis, and inflammation in retired miners with COPD.
Methods: The serum levels of ferritin, soluble transferrin receptor(sTfR), and transferrin saturation(TSat) as biomarkers for iron deficiency and high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation and hepcidin as a biomarker for iron homeostasis were measured in 93 male subjects. Iron deficiency was defined as any one or more of (1) sTfR>28.1 nmol/L, (2) TSat<16%, and (3) ferritin<12 μg/L.
Results: Iron deficiency was found 28% of the study subjects. Median levels of serum hsCRP was significantly increased related to airflow limitation of COPD(GOLD 1, 0.09 ㎍/dL vs. GOLD 2, 0.17 ㎍/dL vs. GOLD 3≤, 0.30 ㎍/dL, p=0.010), and was positively correlated with hepcidin(p=0.009). Mean level of serum hepcidin was lower in COPD subjects with iron deficiency(p=0.004) and serum levels of hepcidin was negatively correlated with %FEV1 predicted(p=0.030).
Conclusions: These results suggest that high serum levels of hepcidin are related to severe airflow limitation or inflammation and can decrease iron availability, regardless of iron status.
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KEYWORD
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chronic obstructive pulmonary disease, C-reactive protein, hepcidin, iron deficiency, retired miner
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